I would say not 'possible', but more probable than in 2016.
We'll be seeing its hints in 2022 and it will be full bore in 2024. If the holders of the old-guard strategies (McCain 2008/ Biden 2020 style campaigns) want to not get trounced in 2024, they need to make a substantial difference in peoples lives to win that election. Otherwise, 'Trumpian' style campaigns will become the norm, as they'll be show to be more effective at winning elections.
Might actually be more riding on 2022/ 2024 than 2016. 2016 proved it possible; these next elections will decide if its reproducible.