For prototyping purposes I'd like to see a comparison of building a twitter clone in MySQL, MongoDB and there's already one in Redis http://redis.io/topics/twitter-clone MySQL will require the most boilerplate here, setting up schemas etc.
I think a lot of our perceptions about technologies are influenced by the things that sit between us and those technologies. A lot of the talk about this particular issue has nothing to do with Relational databases or key/value stores.
In other frameworks, you use your tool of choice to change the database schema, then build the project and you're done. All the "model" stuff regenerates automatically. Thus, schema/model changes have no pain associated with them whatsoever, so there's no particular advantage to using nosql vs sql.
The added bonus of a build step is that you don't need to keep regenerating the same classes and SQL code every page load, but it's not really any different from the programmer's standpoint.