How far will these civilizations crumble? What will they use for energy, given that we have exhausted the easily accessible sources of coal and oil?
"Spreading throughout the galaxy would certainly be harder if nothing like mind uploading (which I'll discuss in a future piece, and which is part of why I think future space settlements could have "value lock-in" as discussed above) can ever be done."
"Mind uploading" is the wrong way to look at it. How about "mind copying" for a best case (whether that copying requires the destruction of the original is another issue); "mind simulation" is a less palatable case.
"But space expansion seems feasible, and our galaxy is empty. These two things seem in tension. A similar tension - the question of why we see no signs of extraterrestrials, despite the galaxy having so many possible stars they could emerge from - is often discussed under the heading of the Fermi Paradox."
Absence of evidence is not evidence of absence. (Yeah, that's pretty lame.)