The word "prion" is actually a contraction of the words "protein" and "infection". (edit: although I agree it's not what one might conventionally think of as an "infection")
A portmanteau word is similar to a contraction, but contractions are formed from words that would otherwise appear together in sequence, such as do and not to make don't, whereas a portmanteau is formed by combining two or more existing words that all relate to a single concept.
https://en.wikipedia.org/wiki/Portmanteau
"Motel" and "fog" are portmanteaus, because you wouldn't put "motor hotel" or "smoke fog" in sentences that accept the accretions, whereas you could swap "prion" for "protein infection".
"Motel" and "fog" are portmanteaus, because you
wouldn't put "motor hotel" or "smoke fog"
s/b "Motel" and "smog" are portmanteaus, because you
wouldn't put "motor hotel" or "smoke fog"(Aside from actual domain experts in this thread saying it is an infection, that is).
Is the difference between an infection and poisoning replication?