Socially speaking, I would say that conservatives were generally fair game to make fun of or put down in some way most of the time. Sometimes it would be making fun of rednecks or hillbillies or maybe the Amish. Luddites were fair game to be made fun of. Oftentimes it was less about humor and put downs, but more about moral superiority. This was just my experience, and I'm sure other liberal/progressive/whatever people are struggling to feel accepted in their conservative social circle.
Now that I'm conservative, I talk a lot less about what I think in mixed company. It's simply too risky.