Having the right setup is not only about making your brain more productive - it's about keeping your spine pain free. While my home office is set up for this purpose, only one company that I have worked with so far had this aspect in mind. In the past, I had to take days off because of terrible set ups and long work hours. Having a well positioned and large second monitor helps a lot.
You have much more control over this while designing your home office. Working from bed is not the way unless you're planning to marry a physiotherapist in the future.