But nobody (as far as I know) who has used TypeScript wants to go back to vanilla JavaScript. I find that fairly telling.
I think at least for UI work there is a lot of space for dynamic plumbing together of well typed components. Components in this case meaning actual UI components as well as modules of business logic or state management.
On personal projects I only want to deal with builtin browser technologies, there is no npm, webpack, tsc, yarn, whatever, just plain <script/> tags.