Back in the skeuomorphism era, Twitter offered an awesome and innovative iPad app (version 4.x) that had a UX design based on three overlapping layers with navigation tabs on the side. One could effortlessly switch between your own timeline, another user's timeline and a series of tweet threads. With the amount of visual elments on screen it was very information dense and easy to follow. I had just bought a retina Gen3 iPad and instantly fell in love with the experience.
The next major version update was a huge disappointment as they decided to take away all the good and unique things out of the app and make it just another clone of their mobile web interface which just looked barren on the iPad screen. Fortunately I had a backup of the old version which I was able to restore but still had a sour taste in my mouth knowing this version might stop working any day from then.
I did try other 3rd party clients but none was as good as the good old official one. The same design was copied by Weibo for their iPad app which held out a bit longer but eventually it went the same way Twitter had.