The smart thing to do is to pull $1m out every week or so - big exchanges have the capacity to do that much.
In the case of the most naive lender in the world who does this, you will be bitten by their incompetence in some other unrelated way almost immediately.
In the case of any competent lender who knows anything about Bitcoin, they would go "way too liquid" and "haha nope".
</uninformed_commonsense_guess>
So you could have your $100M loan in the bank one day, and have to pay it all back (including what you spent) after a bad bitcoin day.