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I am not an expert, nor a doctor, but the article being discussed said that Guanfacine causes sedation (and Wikipedia says it is indeed currently prescribed sometimes as a sleep aid) and that users might have to build up a tolerance to the drug to minimize its sedative effects.

Can't see more than the summary of the study you pasted, but it seems to suggest one single dose was tested per person. Wouldn't this maximise the sedative penalty?

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From anecdotal evidence I've heard from people taking this stuff, it doesn't help much with memory/cognitive ability, but does help control impulsive urges which can act as a hindrance to cognitive and memory tasks.

If you are not suffering from overactive impulses, this may not do much to help you function and may in fact hinder you by providing an additional sedative effect.

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