It feels a bit to me like you're reiterating a myth. I've used opera for 5 years and I've never run into this, afair. I virtually only get problems when devs use browser detection and then tell me that "this site does not work on opera". I've also had problems with sites that were just only tested on Firefox (used to be IE but the short-sighted devs all switched browser), but there it didn't work on Chrome either.
Of course, this is just anecdotal evidence, but I think comments like yours are what keeps some people from trying out an excellent browser that does what you want and nothing else.
The only thing that I think really rocks more in Chrome is its super-smooth and entirely hidden auto-updating mechanism.