It's on a case by case basis, but try saying "I do not wish to discuss my personal life at work" in response to any questions about your personal life, and see how it goes :)
Caveat: You have to be in a large company with a lot of managers.
Caveat: You have to be in a large company with a lot of managers.
Saying "It's none of your business and you can't force me to answer" send a very different message than "It's going alright. Did you watch the game last night? Pretty cool, huh?"
No one will bat an eye at that answer. There are some managers / employees / peers where I know their personal life well and there are some I don't know at all. It has never been relevant.