Years ago, I became immune to having reactions to mosquito bites after getting bitten over a hundred times in a 20-hour timespan by at least 3 types of mosquitoes, one of which was Aedes Aegypti (the stripey bastards that carry Dengue Fever).
I always knew that the redness, itching, and swelling was an autoimmune response to the introduction of certain proteins present in mosquito saliva, so I'm wondering if it's possible to override that response by introducing enough saliva (with myself as a prime example), and what the wider implications of that are.