New study examines ‘Achilles heel’ of cancer tumours | Hacker News Reader

New study examines ‘Achilles heel’ of cancer tumours

med.ubc.ca

151 pointsevo_920 comments

As others stated, this is really a PR piece.

The study aim was to see what the tolerable dose for a future study might be. 17 patients ranging from metastatic breast ca to unresectable colon ca were studied from 2014-2016.

Patients were given either 500, 1000, or 2000mg of what must be a truly horrible liquid to drink and then watched for adverse outcomes.

Most patients discontinued treatment due to disease progression, and patients in the 2000mg dosage group had trouble tolerating the medication.

Anyway, not to knock the study, hope things pan out, but to market this as the "achilles heel of cancer" is, well, a bit hard to swallow.

But I think the point is not that they found a chemical that can inhibit CA, it's the idea that targeting CA could be useful. From that point of view, CA dependence really is the "Achilles' heel" of tumors, since tumors (presumably) require vascularization, CA prevents hypoxic regions from acidifying and CA inhibitors will halt tumor growth.

If the initial chemical this team found is not good, no problem, another can be found.

Interesting that I found, on a hunch, that aspirin is also a CA inhibitor[0] (could explain some of its cancer-reducing effect), and further that aspirin derivatives are also promising CA inhibitors[1] (targeting CAIX).

Putting all that together it seems there's a ripe avenue of research for targeting the Achilles' heel of tumors: find CA inhibitors derived from already well-tolerated cheap widely available generic drug (aspirin), and pursue those that are safe and effective in humans. I'm optimistic! :P ;) xX

[0]: https://www.mdpi.com/2218-273X/10/4/527

[1]: https://pubmed.ncbi.nlm.nih.gov/33844134/

We have had a new "breakthrough" in cancer treatment every other week for the past 30 years now.

I'm not saying progress won't come, but any article claiming a "breakthrough", "achilles heel" and so on, probably is just PR bull s*t.

The phase 1 study mentioned in this article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323835/

("Dr. Dedhar and colleagues previously identified a unique compound, known as SLC-0111—currently being evaluated in Phase 1 clinical trials—as a powerful inhibitor of the CAIX enzyme")

> known as SLC-0111

https://scholar.google.com/scholar?q=%22SLC-0111%22

AND

"U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model. "

For research use only. We do not sell to patients.

100 mg: EUR 292

https://www.medchemexpress.com/U-104.html

Dumb question: why do all tumours have this in common? Do they all develop it independently? Or: Is it something that healthy cells would also do, were they to be put into the same acidic conditions? Or something else?

This is really early stage research being filtered through a PR team, so don't read too much into the results here yet in terms of whether all solid tumors actually have this in common and if it's actually an Achilles heel - cancer is very good at mutating and developing resistance. Here's some speculation on whats going on here. First, a useful tautology in natural selection - for a cell to be able to survive in an environment, it has to be able to survive in said environment. So the reason all solid tumors would have this is in common is because they share acidic environments (a side effect of low oxygen environments created by the tumors themselves), so they all would have adaptations to survive in these environments. Tumors are naturally hypermutative, so they have some evolutionary advantages when it comes to developing resistance. Statistically, this particular gene being unregulated might be the easiest way to develop acid resistance, so we see that most often. I would be unsurprised if after inhibiting this enzyme, we saw new approaches pop up - cancer mutates fast. Healthy cells would likely have a much harder time surviving in these environments (though most solid tumors have tons of healthy cells - they might be getting protection from the tumor cells or using some other mechanism). For those healthy cells, if their DNA is more stable or they don't replicate as quickly as cancer cells, they're going to have a hard time adapting, unless this is a general stress response mechanism that's really easy to upregulate. If it is a general response, I'd be curious about the general use cases for the enzyme and what the side effects would be of inhibiting it.

Sorry it's not a straightforward response, but even with very well understood cancer genes, the narrative is never as simple as what these PR articles state, and especially for a recent discovery, its quite a claim to say that you've found a general Achilles Heel for solid tumors, an incredibly diverse class of tumors that are by their nature highly evolutionary unstable and quickly adapting, and also similar enough to normal cells that its hard to discriminate between the two with drugs.

I don’t know if you know the answer to this but one thing that I have noticed in any personal research into cancer therapy trials is that it seems that many organizations are looking for single drug treatments, potentially to the exclusion of including other drugs in trials.

Anyone that has been through chemo knows that this is not where it ends up most of time, but it really seems like companies are trying to push monotherapies as much as possible.

For example, antiangiogenic drugs that help reduce the vascularization of tumors would seem to be a perfect complement to this, but if you look at the phase 1 trial there were no other drugs included in the study. I can certainly understand why it makes sense to focus on the effects of a single pharmaceutical, but in order to blend doses they’re going to have to go back to a trial most likely to see the effects of the compound treatment. This takes time that many people don’t have.

Any single agent will usually need to prove itself as somewhat efficacious on its own. Almost certainly, safety (phase 1 trial) will be tried as a single agent before trying combination therapies.

However, some of our best chemotherapy regimes are combinations of many agents, such as FOLFOX and FOLFIRI in colon cancer. But to get there was a long process.

There is an idea of synthetic lethality, where a single gene getting shut off by a drug has no effect, but combining (the synthesis part) with a second gene getting shutoff causes cell death. This is an extreme case of epistasis (my gene name), but the challenge of doing trials with this is that the search space is quadratic or worse, rather than linear. And number of people enrolled in clinical trials is an extremely valuable resource.

Which is what leads to making sure that we start with single agent trials, to prove both safety and hopefully efficacy of these single agents. The combinations come later, because they are so complex and difficult in terms of finding something with efficacy and in terms of managing side effects and adverse events.

What you're saying makes complete sense. I just struggle at times with decisions like these because because there are millions of people sick today where the disease has broken through Avastin's ability to constrain tumor size and this might be what's needed to put it over the edge.

On the other hand, anti-angiogenics are frequently not even made available in a post surgery context, particularly if perforations are a concern, so having some kind of agent that can throttle tumor growth without impacting compromised tissue would be a benefit.

I guess there are no good answers until we can do whole body simulations to test drugs and all of their corner cases en masse.

Mice one step closer to being immortal.

You’re not wrong, but this is closer than a lot of the research posted here: it’s in Phase 1 trials, so it is at least starting to move into human subjects.

So this method won't work on cancers without tumor.

It would be great if it did, but we’ve made great strides in a lot of non-solid tumors. They are much more targetable, it is easier to get a small molecule to the problem cells. Admittedly, some tumors like GBM without a single mass remain death sentences - but a lot of blood cancers are much better than they were 20 years ago.

I'm always skeptical of claims of a cancer cure-all. I think the key to curing cancer will be to discover a method of rapidly finding cures for individual cancers, as each cancer is unique and will need a personalized approach. The immunotherapy approach is having success because broadly speaking, it does this.

...in mice

Original source without lots of ads: https://www.med.ubc.ca/news/new-study-examines-achilles-heel...

Thanks! Much better!

Sounds like good news. Let’s hope it works out…

What a completely different user experience.

Changed to that from https://www.walesonline.co.uk/news/uk-news/cancer-treatment-... above. Thanks!

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