Can someone help me understand the possible negative impact of running ublock? Eg do some sites not work unless you disable it, etc? If so how do you go all-in on ublock without undue frustration?
If you run into repeated problems you can set permanent rules allowing certain domains. Overall it's a very minor hassle in the scheme of things.
Anecdotally - I've visit only few sites that were totally blocking their work, all of them were piracy related sites.