Hayley Arceneaux will become the first individual with a prosthesis to go to space. In the 60 year history of crewed spaceflight, we have never put a human with titanium bones in orbit. Nor, have we sent anyone up who has met any of the requirements to be otherwise classified as "disabled". Until now.
It is the indicator of a profound tipping point.
The very first astronauts were required to be "perfect physical specimens" (cis-male specimens at that) that had no abnormal readings in all of their medical tests. Jim Lovell was eliminated from consideration during the Mercury program because of his elevated bilirubin levels, which turned out to be a fairly normal variation of human physiology.
The requirements loosened to the point where Jim Lovell could go to the moon. But most people, including women, were still excluded by NASA's and the Air Force's Flight Surgeons.
Then came the Shuttle program that opened the field wider to more bright minds who wouldn't have met the "perfect male physical specimen" standard, including Eileen Collins and Sally Ride. By the end of the program, the shuttle had launched multiple cancer survivors into space.
However, so far, people who are considered "disabled" or "unfit" by the Flight Surgeon's office are still excluded. These terms cut a wide swath and include treatable conditions such as, Type-I diabetes, dysmenorrhea, endometriosis and - yes- prosthetics. Other than a call by ESA for the first disabled state-sponsored astronauts, no other astronaut corps has admitted someone like Hayley into their ranks. Yet.
With this flight, Hayley will set a new milestone in space medicine. A big one. She will become a test case that can be used to demonstrate that people with disabilities can function and operate in the spaceflight environment. It will break the cycle of disabled people being "flight proven", from a flight surgeon's perspective.
We're now at the dawn of a new age, where anyone physically fit can go to space, provided they have the mental aptitude. It's incredible.
This flight means that I can be an astronaut. And so can you.
Hayley represents a huge milestone. And we owe it to commercial spaceflight. Thank you, Elon and Jared Isaacman (and Axiom Space).
edit: This comment is one of my more downvoted comments. I'm not sure why.