If you need a job, you gotta play the game. Mass applying is the current meta game.
After seeing it from the hiring side for the past 7 years, I can also say that there's usually a few extra unlisted criteria that would more than substitute for the skills you don't match on. The content of job listings is largely true to the desires of the hiring manager but also incorporates some organizational inertia. It takes a while to get new technologies incorporated into the practices of recruiting offices. Many managers are usually informally hiring for skills that have not yet achieved enough of a foothold to be a screening criteria.
Of course, if you apply to a large number of jobs and don't get any callbacks then that's a strong signal that you either need to update your resume, update your credentials, or seek employment in another field.