At this point I would be fine with starting with the baby set of killing any patent that implements a business process. It would be a good start, simple to explain, and kill off a goodly chunk of the trolls.
One click and most of Loadsys's patents are really biz process patents implemented with technology.
Sorry, I should have been more specific. My point is more that the problem is systemic. You also can't patent something that has prior art, but it happens all the time.