It really depends on what the app is though, yeah? If I'm in document processing or spreadsheet where you might be working for long periods where a 5min auto-save kicks in could be convenient. However, when I'm writing code that then needs to make rapid changes like updating CSS/JS/etc to be refreshed in browser, then I'm not waiting 5 mins for an autosave. Cmd-S, Cmd-tab, Shift-Cmd-R, boom.
However, Cmd-S is so engrained into the muscle memory, that it's almost instinctual to hit it after every press of a semi-colon.