Any site you visit could be compromised, but since the only 100% safe course of action is to completely disconnect from the web, blocking the most obvious vectors entirely seems appropriate. Of course, not only are ad networks vectors for malware, they don’t even serve a useful purpose to you that might justify the risk.
Not sure how todays safety is in that regard.
Browsers have gotten better and updates have gotten much faster, so less of that is drive by virus infections by exploiting the browser, but there's still cases of "Pick some users that you think are (a) real users and (b) naive enough" and serve them a exe download that contains a virus.
For a project that didn't directly make money (there are some 'cloud' offerings now), Safe Browsing probably was a very high return on investment.
I had one user that was hitting tech support scams monthly. He would go to Google, search for Amazon, then click the first link on the page (which always had the little Ad word next to it).