Several times now, I've accidentally Cmd+Q'd Chrome because I didn't realize that TextEdit or Preview was no longer the application in focus.
This happens mostly if I just closed the last of the application windows, and accidentally expose'd the windows back and forth. If you "Show Desktop" and then bring the windows back, TextEdit and Preview will now be closed.
I don't think I like it, but it might just be a matter of retraining myself.