I don’t doubt that one can do mental things to put one’s mind in an unusual state long term (nor that differences from these unusual states can be observed with a measurement device).

What I doubt is that doing so is prudent.

When you look at the ambiguously labeled knobs and levers in the locked control panel of your mind, is it really a good idea to pick the lock and mess around with the levers?

(Also, why would I even want to change whether a thing would cause my mental reaction to be “suffering”? Either “suffering” refers to something other than what I generally mean by the word, in which case, well, whether it is a benefit would depend on what that meaning is (but the default would be not to mess with things beyond my ken) , or it does, in which case, uh, no, I’d rather not be wireheaded kthx. Along the lines of https://www.smbc-comics.com/comic/utilitarian-time-travel , if the baron would impale me on a pike, my preferred solution would be to prevent that, not to have a neural restructuring beam make it so I love getting impaled. )