This was the reason we ended up moving away from B2. It may be durable but their storage isn't a drop-in replacement for S3 or similar products. They are really an S3-compatible target for backup softwares.
I don't mind services that cut price dramatically in exchange for only supporting some (not all) use cases. That can be a very attractive offer, but does Backblaze explicitly position B2 for non-interactive use cases?