That depends on the applicable Senate rules (including any special one-time exceptions) at the moment when it is considered. Constitutionally, no, because supermajority cloture isn’t a Constitutional requirement (and, indeed, a key motivation for the Constitution was frustration with the effect of supermajority requirements in the Articles of Confederation making legislation impossible.)
EDIT: To summarize some of the downthread discussion: Assuming no special action, if brought up right now under the existing rules, “yes”.