Even at a safe following distance, the already moving air behind a truck lowers your effective speed by 20mph or so, saving 25-50% of the fuel bill. Trucks that have very little ground clearance (eg a big mudguard across the back) work best.
In the extreme case, in an EV, you can end a journey with more battery than you started with if you follow a truck closely (rather too close for safety, and in perfect conditions)