I can't comment on every use case, but I've recently been using htmx[1] with Django templates to provide sort-of async behaviour. For me it's the best of both worlds; I can specify my template and view as though it's a normal page load, and then use some hx- attributes to make it async.

1. https://www.mattlayman.com/blog/2021/how-to-htmx-django/