Now, let's talk about another area of science. The structure of DNA, or whether electron spin exists or what the shape of the earth is. There are no questions in my mind (beyond the normal ones I have about Descartes' Great Deceiver) that the structure of DNA in aqueous solution at room temperature with 15mM Mg is B-form, very close to what was described by Watson and Crick, or that electron spin exists and that we can use it to do NMR to determine molecular structures. And the planet Earth is an oblate spheroid.
All three of those are so true that if you were able to disprove either, massive areas of science would fall. I cannot imagine any set of data which could falsify any of those three hypotheses in a way that didn't completely tank science.