Tmux is great even if you're not using it as a process manager; it dramatically increased my productivity at the terminal (which is most of my day)
No, you'll want to actually use rxvt-unicode [1] on X11 on your Mac. The X implementation is annoying at times on OS X, but using a great terminal is worth it if you spend all your time in one. iTerm2 is nice, and Lion's new Terminal.app isn't bad, but programs like vim and tmux are designed with real xterm-compatible terminals in mind [2].
[1]: http://dist.schmorp.de/rxvt-unicode/
[2]: For instance, you can enter copy-mode in tmux 1.5 with a mouse scroll if you are using xterm or rxvt-unicode
defscrollback 30000 term xterm-color termcapinfo xterm ti@:te@ # scroll wheel action!
escape ^Tt # Instead of Control-a, make the escape/command character be Control-b