The people who know the most about fructose blame it for the huge public health crisis that the US (and UK, Pakistan, India, and some other countries) are suffering, manifested as insulin resistance and type #2 diabetes, "metabolic syndrome". It kills way more than COVID.
Specifically: fructose is mostly processed only by the liver. (The liver's main job is neutralizing toxins.) Excess fructose is processed on the same metabolic pathways as alcohol, a major toxin. Large amounts of fructose are turned into fat and stored in the liver, like alcohol, and generate uric acid, which causes gout and numerous other problems, like alcohol. (Your kidneys work to try to clear uric acid, but the spikes are harmful.) Today, American children are getting cirrhosis, like alcoholics.
Taken with enough fiber, fructose absorption is delayed long enough that gut bacteria get most of it, instead, where it causes them no problem. Fruits have fructose and fiber, but juice and soda have no fiber. Fructose without enough fiber is slow poison.
A good place to start learning about fructose metabolism is Robert Lustig vids on youtube. (I watch them at 1.5x-2x speed with subtitles, to save time.) Or read his books. Lustig is a respected endocrinologist.