The Fortune 100 company I currently work for had UWP application for some internal needs. The main pain point was that it was distributed to some private instance of Microsoft AppStore, which meant every time we released new version it had to undergo certification process, and then it would take days to actually push it to user's laptops.
We rewrote the app as the Angular web application, and never looked back. Now every time we deploy the new version all users get the update immediately.