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my AD/immune system anecdote: I have an autoimmune disease. Some ADs make the disease flare up. Some (particularly tricyclics) improve the disease's symptoms.

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Tricyclics (and tetracyclics) tend to be incredibly potent antihistamines, which may explain this.

I just looked and desipramine has a Ki of 60 for H1, which makes it sort of a weak antihistamine.

Tricyclics are TNF-alpha inhibitors. I believe that's the MOA in my case.

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