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I'd like use self-hosted dnscrypt-proxy, point pi-hole's upstream to it.

Then dnscrypt-proxy will choose the servers that has lowest RTT and meet your requirement ( if DNSSEC, no log, family filter available) for you.

I even use it with blocklist and allowlist. No need for Pi-Hole, if you don't mind editing the lists directly.

Does it have regex support? That is the Pi-hole killer feature for me.