The E2EE in Signal only protects the actual content of messages. In the case where Signal takes an assertive action, and the users are not paying any attention to their "safety numbers" (probably the most common case) they could in theory get message content with a MITM attack.
With an less assertive action (simply saving the data) Signal could get access to things like contacts and phone numbers.
Tutanota and Protonmail have both been forced in the past to take assertive actions to retain data as a result of legal warrants. Does American law even allow such warrants? If not then perhaps the USA is underrated as a place to base privacy oriented services.