What’s a “real” GUI framework? Maybe you mean one that uses the provided operating system’s APIs directly, sometimes called “native GUIs”.
Most "browser-based" applications don't even get basic keyboard shortcuts right. Only few of them are really usable and not a single one has better functionality then its native counterparts. There is a bit of a bubble around web "apps" created by a startup culture. The problem is that most of those startups die within a few years. I'm not saying that a browser-based app cannot be useful, but it's equally important to be aware that many types of applications require a real GUI. It doesn't have to be native (e.g. Qt is not "native" in the traditional sense), but it needs to be fairly complete and respect platform APIs.