To me, this means that planetscale (and vitess) immediately become less useful for a large class of applications: existing apps that use an RDBMS that you want to scale. Because most existing apps will expect FKs. I haven't tested my employer's application (which has FKs) to see what will happen, but I doubt it will be smooth sailing.
But there's probably plenty of greenfield development where teams would prefer to stick with standards like SQL rather than a proprietary noSQL language, and that seems like a great fit for this solution.