Ultimately it's an experimental fact - a very surprising one when discovered:
https://en.wikipedia.org/wiki/Wu_experiment
In theoretical terms, the equation used to describe all massive fermions known at the time (like the electron) is built out of four-component quantities called Dirac spinors:
https://en.wikipedia.org/wiki/Dirac_spinor
A Dirac spinor can be viewed as composed of two simpler, two-component quantities called Weyl spinors:
https://en.wikipedia.org/wiki/Weyl_equation#Weyl_spinors
You can try to describe a fermion using only one Weyl spinor, but then it turns out that you can't build mass terms (unless you're willing to violate special relativity).
The massless equation you can write down with a Weyl spinor has two plane wave solutions with opposite helicity, left and right. A Dirac spinor combines a left-handed and a right-handed Weyl spinor; the mass term of the Dirac equation "mixes" them, in the sense that if you start out with a Dirac spinor having its left-handed component set to 0, the mass term will cause it to grow at a rate proportional to mass. If you set the mass to exactly zero, you're left with two uncoupled Weyl equations, one for the left-handed component, one for the right-handed one.
Knowing this, and faced with the experimental fact that weak interactions make a distinction between left and right, you write down separate weak interaction terms for the left- and right-handed components of your Dirac spinors. Eventually it turns out that the simplest choice, having only the left-handed components participate in those interactions, is the best fit to experiment:
https://en.wikipedia.org/wiki/Weak_isospin#Relation_with_chi...
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