Hacker News Reader

I wish I knew why these patients can't have alcohol. I mean the biological mechanism. What the relationship is between misprocessing fat and alcohol being deadly.

View on HN

Not sure exactly, but considering alcohol messes with hormonal signaling I'm guessing it throws something out of balance

Edit: Looked up the wiki article, here is their explanation;

>Additional measures are avoidance of agents known to increase endogenous triglyceride levels, such as alcohol

Thx.

https://pubmed.ncbi.nlm.nih.gov/23511381/

Probably more pertinent:

Alcohol changes the structure of the liver cells and slows down the liver’s ability to process fats. This is the second way that triglycerides begin to accumulate and the levels rise. This is also the beginning of fatty liver disease.

https://findpulse.com/what-liquor-raises-your-triglycerides-...

Oh interesting find. Makes sense

I am equally curious. Fatty liver can be a consequence to high alcohol consumption, but people can also have NAFLD. My guess (IANADr) is that alcohol leads to excessive build up of fat in their bodies.

NAFLD is also highly correlated with diabetes, so I wonder if there could be something to learn from studying this or related genes.

Reply on news.ycombinator.com