Your mom-and-pop website's rank is entirely at the discretion of Google's Core Web Vitals measurements (and other SEO KPIs), but Amazon with its dumpster fire search pages with shifting layouts as content is dynamically loaded in....will be just fine.
The biggest websites in the world (Amazon, Google, Facebook, Twitter) try to push you to use their app whenever possible anyway. The web seems to be an incovenience for them, they certainly don't want you blocking any of the myriad scripts they have running under the hood to tally analytics, A/B testing, user sessions recording and whatever else.
If you have a personal website, as I do, chances are it's relatively lean, because we're the only ones designing it and keeping it updated. Chances are also that very few people visit it, because it's outranked by the thousand other bloated websites that will rank higher for whatever query it was that you typed.
So what's the point?