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I tried St John's Wort, I didn't notice any difference.

I went to my GP and was prescribed anti-depressants. They worked. The first two had less of an effect over time, before I built up too much of a tolerance to the third I had talking therapy (Cognitive Analytic Therapy in my case) which ultimately got me out of depression.

Different people respond differently to different drugs/therapies.

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I'm skeptic when it comes to anti-depressants because of their Post-SSRI sexual dysfunction effects http://en.wikipedia.org/wiki/Post-SSRI_sexual_dysfunction The only drug I know that has no dangerous post conditions is St john's wort

Is that that St John's Wort patients have been extensively studied and it has been found not to have any dangerous effects?

Or is that that an insubstantial number of studies on St John's Wort have been carried out?

When I tried to find out about this (years ago, pre-Wikipedia I think) I couldn't find any substantive research.

For all their faults, pharmaceutical products are well-studied, especially the ones that have been on the market for some time.

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