Having a rule of law is not a regulation, is the most basic fundamental prerequisite to having a functioning modern, democratic society. Free markets are built on top of that and regulations come on top of free markets.

And free markets imply free people - slavery is the opposite of that.

Taxing externalities is also necessary, and it's tax, not a regulation. But that is something we're still working on, with little success it seems. See the carbon/pollution international issues with China, Russia, Australia.