I've battled with Python's packaging systems and other tooling and performance problems for more than a decade. Every couple of years some new thing comes along promising to fix package management, but it always fails spectacularly on some important, mainstream package or use case. I suspect a lot of this complexity comes down to the significant degree in which the Python ecosystem depends on C: not only do we need to package Python programs but C programs as well, and some people think we should ship C source code and build on the target machine and others think we should ship pre-built C binaries and dynamically link against them on the target machine thus Python supports both mechanisms; however, both are perilous in the general case.
And interestingly, Python depends so hard on C because CPython is very slow, and CPython is very slow because the C-extension API is virtually the whole of the CPython interpreter (many interesting optimizations to the interpreter would break compatibility in the ecosystem). So it certainly feels like all of Python's major problems come down to this decision to lean hard on C and specifically to make so much of the interpreter available for the C-extensions.
The way out as far as I can tell is to define some narrower API surface (e.g., https://hpyproject.org), get the ecosystem to consolidate around that, deprecate the old API surface, and then make the requisite breaking optimizations such that the ecosystem can feasibly do more in native Python. This requires leadership; however, and the hard truth is this has not historically seemed to be Python's strong suit--the Python maintainers seem unable to drive out big, necessary changes like this (which is certainly not to say that leadership is easy or that I could do better, particularly when Python is so established in many respects).
Personally, I've come to use Go for 99% of my Python use cases and it's been great. There are dramatically fewer C bindings (<1% of the ecosystem by my crude estimation), so the build/packaging tooling and performance are orders of magnitude better than in Python. Static typing works well out of the box, real static binaries are not only feasible but trivial (as opposed to Python where you try to build a zip file with your dependencies and the result is hundreds of megabytes and it's still missing the runtime, std libs, and various .so files). Further still, builds, tests, and every kind of tooling are far faster than with Python, and far simpler to install and manage. Unless you're doing data science, I don't think you'll regret the transition.
EDIT: On the subject of Python to Go, looks like this case study hit the front page shortly after posting this comment: https://gitlab.com/esr/reposurgeon/-/blob/master/GoNotes.ado...