Just to add, it appears there is Google Talk support available in synergy by extension. [1]
Hulu did work via support Flash on webOS. Although it was just recently blocked, there are apparently ways to unblock it. [2]
And I'm sure we're all aware that Yelp can just be bookmarked and used as a website. HTML5 is the future and all that.
[1] http://www.precentral.net/synergy-messaging-plugins-3-0-brin...