With Python, if I publish my script with 100 dependencies, and someone `pip install`s it, they will also end up with 100 packages being copied to their computer.

The main difference is that Python installs them globally (or at least thinks it does, if you're using virtual environments), while .NET apps isolate themselves from each other.

Also, let's make a fair comparison. Is that hypothetical Rust application of yours depending on literally 100 crates? If so, what is the size of your binary?