At work, I've tried it. I've tried hard to like it. I had to stop because Fira Code (and ligatured Iosevka) took the principle of the least astonishment, threw it on the concrete floor and kept beating it down till it stopped breathing, and then some.
I found myself spending time wondering "what characters is this made of?", and "how do I type THAT?" when viewing some existing code, and "WTF is this?" when a ligature that would have likely made sense in Ruby or Haskell (or in APL?) made it into my Perl code.
Also, "is this a ligature or some Unicode glyph?" was a question I found myself asking. In a better world, I shouldn't be wondering about it while fixing some integration with one of Intuit's molochs or somesuch. But here I was.
Switching to non-ligatured text shed a lot of cognitive burden off me. At least I can tell which thing is ASCII and how I type it. And my code doesn't look as a Guillome Apollinaire's calligramme.