5ish years ago it was common knowledge that us-east-1 is generally the worst place to put anything that needs to be reliable. I guess this is still true?
In all seriousness though - even non-regional AWS services seem to have ties to us-east-1 as evidenced by the recent outages. So you might be impacted even if it looks like (on paper at least) you’re not using any services tied to that region.