I think the OP means less about perf and more about dollar cost since you have to either be able to trust the uptime of a storage node (and likely pay more) or make more copies (and therefore pay more) in order to be guaranteed your data isn't lost when a node goes down.

The performance of splitting up files and storing them on multiple nodes tends to be very good since you're not as bottlenecked to one node feeding out all of the bytes (think about bitorrent and how fast it is to download a well-seeded file). That said, network egress might become a problem if the node you're seeding content from lives within AWS or another cloud provider. I don't think this egress price penalty exists in any major ISPs that I know of.