Certainly the cannabis analogues which are not similar to natural cannabinoids are big trouble.
That is, if marijuana harms you the harm is pretty subtle and takes a long time to unfold. Maybe it makes you silly, maybe it stunts your psycho-emotional development, from first principles I'm inclined to think it might cause diabesity but you can't blame cannabis for the diabesity epidemic because most of the diabese aren't users.
Cannabis analogues like Spice and K2 really can kill you right away.
After the CBD bubble popped people realized they could convert CBD to valuable cannabinoids such as Delta-8 and Delta-10 THC. I'm no advocate of those substances but they don't seem to be deadly like the structurally unrelated analogues.