Obviously I would like to be left alone while working, but I have handicapped and mentally ill people to care for my life is acutely interrupt-driven. My work is immensely enjoyable so I can recover pretty fast most of the time.
In the days I did work in an office, I found that I got an enormous amount of work done on evenings, weekends, or very early mornings. This required having a spouse who understood that work was important because it supported both of us.