Bitcoin, Ethereum, Hyperledger, others, none of the above? HN leans to the last option, so this is not the best place to ask. Most of the time, outside of some very specific and narrow blockchain use cases, a non blockchain solution will be easier, cheaper, and safer to build with.
It's largely going to depend on what you are trying to do and the constituents of the network. You should make your question more specific and provide as much context as possible, if you want quality and relevant answers for your inquiry.