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Not an expert but please take a look at https://en.wikipedia.org/wiki/Original_antigenic_sin

Jup, josephcsible mentioned it before and it got me into a rabbit hole that resulted to the following research:

https://www.cell.com/trends/immunology/fulltext/S1471-4906(2...

I'm receiving external feedback based on my findings later on. I have a temporarily conclusion, but it's debatable because of lack of domain knowledge.

Tldr: too early to conclude anything with reasonable certainty

Yes there is so much uncertainty that I think that the best response is to do nothing.

I'm not sure if that's the thing. It seems that "original antigenic sin" was already considered ( as a variable) from the beginning. According to what i read, it could be that mRNA vaccines don't have that problem as much ( or perhaps at all?)

I'm waiting for external feedback though. I'll see what it gives.

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